Fixed-dose combination antihypertensive medications

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Effect of fixed-dose combination (FDC) medications on adherence and treatment outcomes

Low adherence to prescribed self‐administered medication is well documented and particularly problematic in the treatment of chronic or asymptomatic conditions1 2. Even in affluent countries with well developed health care infrastructure adherence to long‐term therapy is estimated to average only 50%3. The implications of poor adherence are substantial at both the individual and population lev...

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Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...

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Withdrawal of antihypertensive medications.

BACKGROUND Pharmacologic treatment of hypertension reduces risks of stroke, congestive heart failure, renal failure, and mortality, but whether medications, once begun, need to be continued for life is uncertain. METHODS Several search strategies on MEDLINE using key words "medication," "withdrawal," "discontinuance," and "therapy" in several combinations, nested within "hypertension," were n...

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Too bad! Fixed dose combination antiretroviral drugs

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Fixed Dose Combination and Disease Management

Fixed dose combinations (FDCs) are combinations of two or more active drugs in a single dosage form. It is the current hot topic of deliberations in the pharmaceutical industry, drug regulatory agency, and the pharmaceutical trade. Surprisingly, it is not so among the doctors who prescribe the medicines or the patients who consume. Basically, from one point of view it increases patient complian...

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ژورنال

عنوان ژورنال: The Lancet

سال: 2019

ISSN: 0140-6736

DOI: 10.1016/s0140-6736(19)31629-0